The in Vivo Effect of Regular Moderate Wine Consumption on Blood Platelet Function, Haemostasis and Human Blood Chemistry


Project Number
THRIP 1239

Project title
The in vivo effect of regular moderate wine consumption on blood platelet function, haemostasis and human blood chemistry

Project leader
Van Velden, D P

Institution
University of Stellenbosch

Team members
Blackhurst, D M

Project description
Our previous studies indicated that the inverse association between wine consumption and coronary heart disease mortality could be attributed to the anti-atherogenic and antithrombotic effect of red wine.

Our present study on 22 volunteers investigated the health effects of a diet designed by the Nutritional Intervention Research Unit, MRC (Mediterranean-like that included South African red wines). During the experimental periods the subjects increased their intake of vegetables, cereals, fruit, mono-unsaturated fatty acids and fish at the expense of red meats and dairy products. Dietary control was by 3-day dietary records, 4 times during the study. Fasting blood samples were taken at the start (baseline), after the diet and after the diet plus wine periods. Wine intake was 180 ml/day equivalent to 23 grams alcohol for women and 250 ml/day equivalent to 32 grams of alcohol for men.

They were monitored for biomarkers of chronic lifestyle diseases such as the metabolic syndrome (adult onset diabetes) and ischaemic heart disease. The tests included anthropometry (body mass index or BMI), blood pressure, fasting lipograms (total, high and low density lipoprotein cholesterols, triglycerides), fasting blood glucose, insulin, platelet aggregation, platelet membrane fatty acids, concentrations of clotting factors VII, VIII, fibrinogen and total antioxidant status of the plasma.

The results proved that the Mediterranean-like diet had a protective effect against the metabolic syndrome, and more specifically on the impaired glucose regulation by significantly lowering the fasting glucose level and the BMI and that there are some significant in vivo antithrombotic effects detectable after 6 weeks on a Mediterranean-like diet that are enhanced by moderate wine consumption. This study indicates that minor lifestyle changes can markedly influence the impaired response to the physiological effects of insulin including those on glucose and lipid metabolism.

Poster(s)
Van Velden, D P. 2001. Cardio-protective effect of wine on human blood chemistry. Poster presented at 26th World Congress of the Vine and Wine and the 81st General Assembly of the OIV. 11-17 October 2001, Adelaide, Australia.

Van Velden, D P. 2001. The in vivo antithrombotic effect of wine consumption on human blood platelets and haemostasis. Poster presented to the New York Academy of Science.

Van Velden, D P. 2001. The in vivo antithrombotic effect of wine consumption on human blood platelets and haemostatic factors. Poster presented at 26th World Congress of the Vine and Wine and the 81st General Assembly of the OIV. 11-17 October 2001, Adelaide, Australia.

Van Velden, D P. 2003. The influence of a Mediterranean-like diet with and without red wine on the criteria related to the metabolic syndrome. Poster presented at the International Conference on Health Benefits of Mediterranean diet: Highlights on Cancer and Cardiovascular Diseases. 5-8 June, Crete, Greece.

Van Velden, D P. 2003. The influence of a Mediterranean-like diet with and without red wine on the criteria related to the metabolic syndrome. Poster presented at the 12th National General Practitioners Conference. 8-10 August, Stellenbosch, South Africa.

Presentation(s)
Van Velden, D P. 1999. An investigation into the in vivo effect of regular red wine consumption on the agreeability of blood platelets. Paper presented at the 24th World Congress of Vine and Wine and the 79th General Assembly of the OIV. 5-9 July 1999, Mayence, Germany.

Van Velden, D P. 2001. The in-vivo anti-thrombotic effect of regular and moderate wine consumption on human blood platelets and haemostasis. Paper presented at the 24th World Congress of Vine and Wine and the 79th General Assembly of the OIV. 5-9 July 1999, Mayence, Germany.

Van Velden, D P. 2002. The influence of a Mediterranean-like diet with and without red wine on the related to the metabolic syndrome. Paper presented at Vinsalud Che 2002. October 2002, Santiago, Chile.

Van Velden, D P. 2002. Platelet and haemostatic changes after a Mediterranean-like diet complemented with red wine. Paper presented at Vinsalud Che. October 2002, Santiago, Chile.

Van Velden, D P. 2002. The influence of a Mediterranean-like diet with and without red wine on the related to the metabolic syndrome. Paper presented at the International Conference on Health Benefits of a Mediterranean Diet. June 2003, Crete, Greece.

Van Velden, D P. 2003. The health benefits of moderate wine consumption. Paper presented at the 12th National General Practitioners Conference, 8-10 August, Stellenbosch, South Africa.

Van Velden, D P. 2004. Platelet and haemostatic changes after a Mediterranean-like diet complemented with red wine. Paper presented at the 28th World Congress of Vine and Wine and the 84th General Assembly of the OIV. 4-9 July 2004, Vienna, Austria

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