The Effect of Regular Alcohol Consumption Interacting with Genetic Risk Factors for Cardiovascular Disease on the Lipopein Profile, Oxidative Stress and Inflammation


Project Number
N09 08-225

Project title
The effect of regular alcohol consumption interacting with genetic risk factors for cardiovascular disease on the lipopein profile, oxidative stress and inflammation

Project leader
Van Velden, D P

Institution
University of Stellenbosch. Faculty of Health Sciences. Department of Pathology

Team members
Kotze, M J
Marnewick, J L
Blackhurst, D M
Kidd, M
Nutt, L

Project description
The effect of regular alcohol consumption on the lipoprotein profile, oxidative stress status and inflammatory markers will be assessed in relation to genetic risk factors for cardiovascular disease.

The specific aims are as follows:
1. Compare the effect of moderate red wine consumption compared to brandy on the atherogenic lipoprotein profile, oxidative stress and inflammatory status.
2. Perform a genetic screen of cardio vascular disease risk factors to determine individual mutation or allele frequencies in the study population
3. Correlate the presence of genetic risk factors with relevant biochemical parameters to compare gene expression in the presence and absence of known environmental triggers
4. Determine the impact of mutations/functional polymorphisms included in the genetic screen on the response to the intervention (small sample size will be a limiting factor).

Presentation(s)
Van Velden, D P. 2008. Response to nutrition intervention and alcohol consumption for the prevention of cardiovascular disease in patients with metabolic syndrome depends on their individual genotype. Paper presented at the Nutrition Congress. September, Pretoria, South Africa.

Van Velden, D. 2010. Health claims on the benefits of moderate alcohol consumption in relation to the genetic profiles. Paper presented at the 4th International Wine and Health Conference. 3-6 October, Friuli, Italy.

Article
Mansvelt, E P G, Fourie, E, Blackhurst, D M, Kotze, T, Stofberg, H, Van der Merwe, S, Kotze, M J, Van Velden, D P. 2007. The influence of a Mediterranean diet with and without red wine on the haemostatic and inflammatory parameters of subjects with metabolic syndrome, South African Journal of Enology and Viticulture, v. 28 (1) (p. 37-43)
Article.pdf

Van Velden, D P, Van der Merwe, S, Fourie, E, Blackhurst, D M, Kidd, M, Kotze, M J, Mansvelt, E P G. 2007. The short term influence of a Mediterranean-like diet and mild exercise with and without red wine on patients with metabolic syndrome, South African Journal of Enology and Viticulture, v. 28 (1) (p. 44-49)
Article.pdf

Kotze, M J, Van Velden, D P. 2011. Waar staan ons nou met alkohol en gesondheid? Wineland, Mnth Oct (p. 133-136)

Van Velden, D P, Kotze, M J, Blackhurst, D M, Kidd, M. 2011. Health claims on the benefits of moderate alcohol consumption in relation to genetic profiles, Journal of Wine Research, v. 22 (123-129)

Van Velden, D P. 2011. Gesondheids voordele van wyn is afhanglik van interaksie tussen gene en omgewing, WineLand, Mnth Aug (p. 106-107)

FinalReport.pdf

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