The Influence of Red Wine in the Prevention of the Metabolic Syndrome and Insulin Resistance

Project Number
2673

Project Title
The influence of red wine in the prevention of the metabolic syndrome and insulin resistance

Project Leader
Van Velden, D P

Institution
University of Stellenbosch, Department of Pathology

Team Members
Mansvelt, E P G

Project Description
It was our aim to investigate the potential health benefits of moderate wine consumption as part of the Mediterranean diet on patients with the metabolic syndrome. We decided to combine moderate wine consumption with the Mediterranean-like diet because wine does not work in isolation, but as part of a healthy and balanced diet.

In contrast with the beneficial findings on health with our study on healthy subjects, patients with the metabolic syndrome did not demonstrate any statistical significant differences in any of the biochemical parameters that were measured during the intervention period.

The explanation for these rather surprising findings could be found in the genotype of these subjects. The genetic assessment demonstrated different combinations of genetic risk factors that may interact with diet and lifestyle factors, unique to each individual tested. Some genetic abnormalities require lifelong drug treatment, and those at genetically increased cardiovascular risk can be managed only effectively by dietary and other lifestyle modifications.

Poster(s)
Van Velden, D P. 2003. The influence of a Mediterranean-like diet with and without red wine on the criteria related to the metabolic syndrome. Poster presented at the International Conference on Health Benefits of Mediterranean Diet: Highlights on Cancer and Cardiovascular Diseases. 5-8 June, Crete, Greece.

Van Velden, D P. 2004. The influence of a Mediterranean-like diet with and without red wine on the criteria related to the metabolic syndrome. Poster presented at the 28th World Congress of Vine and Wine and the 9th General Assembly of the OIV. 4-9 July, Vienna, Austria.

Presentation(s)
Van Velden, D P. 2003. The health benefits of moderate wine consumption. Paper presented at the National General Practitioners Congress. 8-10 August, Stellenbosch, South Africa.

Van Velden, D P. 2004. Platelet and haemostatic changes after a Mediterranean-like diet complemented with red wine. Paper presented at the 24th World Congress of the Vine and Wine and the 9th General Assembly of the OIV. 4-9 July, Vienna, Austria.

Van Velden, D P. 2006. The acute influence of a Mediterranean-like diet with and without red wine on patients with the metabolic syndrome. Presentation at the 50th Academic Year Day, University of Stellenbosch, 16 August, Bellville, South Africa

Van Velden, D P. 2006. The acute influence of a Mediterranean-like diet with and without red wine on patients with the metabolic syndrome. Paper presented at the 29th National Congress of the South African Society for Enology and Viticulture, 14-17 November, Somerset West, South Africa

Van Velden, D P. 2007. Response to nutrition intervention and alcohol consumption for the prevention of cardiovascular disease in patients with the metabolic syndrome depends on their individual genotype. Paper presented at presented at 3rd International Congress on Wine and Health: WineHealth 2007. Bordeaux, France.

Articles
Mansvelt, E P G, Fourie, E, Blackhurst, D M, Kotze, T, Stofberg, H, Van der Merwe, S, Kotze, M J, Van Velden, D P. 2007. The short-term influence of a Mediterranean-type diet and mild exercise with and without red wine on patients with the metabolic syndrome, South African Journal of Enology and Viticulture, Mnth 28 v. 1 (p. 44-49)

 
Van Velden, D P, Van der Merwe, S, Fourie, E, Kidd, M, Blackhurst,D M, Kotze, M J, Mansveldt, E P G. 2007. The influence of a Mediterranean Diet with and without red wine on the haemostatic and inflammatory parameters of subjects with the metabolic syndrome, South African Journal of Enology and Viticulture, v. 28 (1) (p. 37-43)

Article.pdf

Note
Journal articles serve as Final Report.

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