N07 09 203-2017
The role of moderate alcohol consumption in promoting improved disease outcome in multiple sclerosis (MS). An investigation involving transformation training to persons from previously disadvantaged groups in South Africa.
van Rensburg, S J
Stellenbosch University. Division of Chemical Pathology
Erasmus, R T
Multiple Sclerosis (MS) is characterised by demyelination within the central nervous system (CNS), which may result in neurological disabilities over time, causing considerable hardship to patients and their families, in addition to being costly to treat.
Disability progression is a major problem in MS, and there is no consensus as to the causes thereof.
The aim of the MS research project at Tygerberg is to identify factors that predispose to or protect against disability progression (Van Rensburg et al. 2006). Pathology supported genetic testing (PSGT) was developed to integrate relevant patient information (family history, lifestyle, alcohol intake by means of Gkowmix questionnaire), and biochemical measurements (iron studies, lipid profile, vitamin D) with genetic tests to provided health information to clinicians and their patients.PSGT will be used for the proposed study.
The present funding application aims to address the role of alcohol in protecting against disability progression in a group of study participants (25 patients with MS and 25 healthy controls) using three different research methods, while at the same time proving training opportunities to four persons from previously disadvantaged as outlined below.
1. Ultrasound measurement of blood flow in blood vessels of the neck, taking account of alcohol intake of the participants
2. Brain magnetic resonance imaging (MRI) of MS and controls to evaluate fractional anisotropy (FA) in relation to alcohol intake
3.Measurement of Advanced Glycation End Products (AGEs) in serum samples of MS patients and controls in relation to alcohol intake
van Rensburg, S J, Davis, W, Geiger, D, Whati, L, Kidd, M, Kotze, M J. 2016. Effects of diet, smoking and alcohol consumption on disability (EDSS) in people diagnosed with Multiple Sclerosis. Paper presented at the 38th International Conference of the South African Society for Enology and Viticulture. 23-25 August, Somerset West, South Africa.
van Rensburg, S J. 2017. A successful approach to the management of MS using a Lifestyle Regimen. Paper presented at the Pan African Congress of Integrative Medicine. 4-6 May 2017, Stellenbosch, South Africa.
Herbert, E, Engel-Hills, P, Hattingh, C, Fouche, J P, Kidd, M, Lochner, C, Kotze, M J, Van Rensburg, S J. 2018. Fractional anisotropy of white matter, disability and blood iron parameters in multiple sclerosis, Metabolic Brain Disease, Mnth April v. 33 (2) (p. 545-557)
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