Protective Compounds in South African Red Wines


Project Number
UCT SL 12-01

Project title
Protective compounds in South African red wines

Project leader
Lecour, S

Institution
University of Cape Town. Faculty of Health Sciences

Team members
Lamont, K
Cluver, P
Lacerda, L
Lategan, B
Zulfah, A
Vivier, M

Project description
Research has shown that red wine contains chemicals such as resveratrol that protect the heart from model heart attacks. Our recent research has identified in experimental models another protective compound found in wine called melatonin, which is a powerful antioxidant. Here, we propose studying the melatonin content of South African red wines and to explore a possible correlation between the content of melatonin in wine and its cardioprotective effects against a heart attack.

Presentation(s)
Lecour, S. 2012. Melatonin in red wine keeps the cardiologist away. Paper presented at the 1st Workshop on Pineal Gland Melatonin: From Biology to Clinical Application. 13 March, Brescia, Italy.

Albertyn, Z. 2012. Red or white wine: Which one should you drink to protect your heart? Paper presented at the 40th Congress of the Physiology Society of Southern Africa. 10-13 September 2012, Stellenbosch, South Africa.

Lecour, S. 2014. Melatonin in red wine for cardio-protection. Paper presented at 32nd International Society for Heart Research. 3-6 July 2014, Barcelona, Spain.

Maarman, G. 2014. Cardio-protective effect of melatonin on cardiac function in pulmonary hypertension. Paper presented at the RAAS Satellite Meeting. 11-12 July 2014, Stellenbosch, South Africa.

Maarman, G, Blauwet, L, Blackhurst, D, Sliwa, K and Lecour, S. 2014. Melatonin as a novel cardio-protective therapy in pulmonary hypertension. Paper presented at the 15th Annual South African Heart Congress, 16-19 October 2014, Durban, South Africa.

Lecour, S. 2015. Is wine good for your heart? Presentation at the 4th Annual Perioperative Cardiothoracic Congress. 11-14 November 2015, Cape Town, South Africa.

Nduhirabandi, F. 2015. Mechanisms of cardioprotection with dietary melatonin. Paper presented at the European and South African Cardiovascular Research Workshop. September.

Lecour, S. 2016. Melatonin is an important cardiac protective compound found in wine. Paper presented at the 38th South African Society for Enology and Viticulture Conference. 23-25 August, Somerset West, South Africa.

Article
Lamont, K, Blackhurst, D M, Albertyn, Z, Marais, D, Lecour, S. 2012. Lowering the alcohol content of red wine does not alter its cardioprotective properties, South African Medical Journal, Mnth Jun v. 102 (6) (p. 565-567)

Maarman, G, Blauwet, L, Blackhurst, D, Sliwa, K, Lecour, S. 2014. Melatonin as a novel cardioprotective therapy in pulmonary hypertension, SA Heart Journal, v. 11 (4) (p. 185)

Maarman, G J, Blauwet, L, Blackhurst, D M, Sliwa, K, Lecour, S. 2014. Cardioprotective effect of melatonin on cardiac function and oxidative status in pulmonary arterial hypertension, Cardiovascular Research, Mnth Jul v. 103 (p. S90)
http://dx.doi.org/10.1093/cvr/cvu091.167

Lamont, K, Notuhairabandi, F, Adam, F, Thomas, D P, Opie, L H, Lecour, S. 2015. Role of melatonin, melatonin receptors and STAT3 in the cardioprotective effect of chronic and moderate consumption of red wine, Biochemical and Biophysical Research Communication, Mnth Oct v. 465 (4) (p. 719-723)

Lamont, K, Nduhirabandi, F, Adam, T, Thomas, D P, Opie, L H, Lecour, S. 2015. Role of melatonin, melatonin receptors and STAT3 in the cardioprotective effect of chronic and moderate consumption of red wine, Biochemical and Biophysical Research Communications, Mnth October v. 465 (4) (p. 719-724)
https://doi.org/10.1016/j.bbrc.2015.08.064

Maarman, G, Blackhurst, D, Thienermann, F, Blauwet, L, Butrous, G, Davies, N, Sliwa, K, Lecour, S. 2015. Melatonin as a preventive and curative therapy against pulmonary hypertension, Journal of Pineal Research, Mnth Oct v. 59 (3) (p. 343-353)
http//doi.org/10.1111/jpi.12263

Maarman, G J, Blauwet, L, Blackhurst, D M, Silwa, K, Lecour, S. 2015. Cardioprotective effect of melatonin on cardiac function and oxidative status in pulmonary arterial hypertension, Journal of Pineal Research, Mnth Oct v. 59 (3) (p. 343–335)
http://dx.doi.org/10.1111/jpi.12263

Opie, L, Lecour, S. 2015. Melatonin, the new partner to aspirin? Lancet, Mnth Feb v. 385 (9970) (p. 774)
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(15)60438-X/fulltext?rss%3Dyes

Nduhirabandi, F, Lamont, K, Albertyn, Z, Opie, L, Lecour, S. 2016. The role of toll-like receptor 4 in melatonin-induced cardioprotection, Journal of Pineal Research, Mnth January v. 60 (1) (p. 39-47)
doi: 10.1111/jpi.12286

Opie, L, Lecour, S. 2016. Melatonin has multi-organ effects, European Heart Journal Cardiovascular Pharmacotherapy, Mnth Oct v. 2 (4) (p. 258-265)
http://doi.org/10.1093/ehjcvp/pvv037

Dissertation

Lamont, K. 2012. The role of melatonin in red wine induced cardioprotection. Ph.D (Medicine) University of Cape Town, Cape Town.

Maarman, G. 2014. Novel cardioprotective strategies in pulmonary hypertension. Ph.D (Medicine) University of Cape Town, Cape Town.

Thesis
Dlamini, L. 2015. Exploring the cardioprotective effect of synthetic wine in Long Evan rats. M.Sc (Medicine) University of Cape Town, Cape Town.

– Record end –

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