Cardioprotective Compounds in South African Wines

Project Number
UCT SL 17-01

Project title
Cardioprotective compounds in South African wines

Project leader
Lecour, S

University of Cape Town. Hatter Institute

Team members
Adam, T
Blackhurst, D
Nduhirabandi, F
Bauer, F
Maarman, G
Tshaka, M

Project description
We have unexpectedly and for the first time identified in experimental models a cardio protective compound found in wine called melatonin, which is a powerful antioxidant. Our latest data suggest that melatonin is present in both red and white South African wines, with higher concentrations being observed in Pinotage and Sauvignon blanc. Following our current study we propose to pursue our research on the melatonin and melatonin isomers content (these isomers have been recently discovered in Italian wines by our colleagues from the Department of Agriculture, University of Milan) in South African wines with the objective to further explore the correlation between the content of melatonin/melatonin isomers in wine and their health benefits against cardiovascular disease.

Our novel proposal is that the health benefit associated with a chronic moderate consumption of wine may be related to melatonin/melatonin isomers and may be enhanced by increasing the melatonin/melatonin isomers content. Melatonin and melatonin isomers may improve the quality of grapes exposed to stressful physical conditions. Increased melatonin or melatonin isomers may benefit both the quality and the health benefit of South African wines.

Lecour, S. 2018. Wine and cardioprotection. Paper presented at the 5th International Symposium New Frontiers in Cardiovascular Research. 22-24 June, Sapporo, Japan.

Lecour, S. 2017. Melatonin and Cardioprotection: hype or hope? Paper presented at the Annual Congress of the European Society of Cardiology. 26-30 August, Barcelona, Spain.

Opie, L, Lecour, S. 2016. Melatonin has multi-organ effects, European Heart Journal Cardiovascular Pharmacotherapy, Mnth October v. 2 (4) (p. 258-265)
doi: 10.1093/ehjcvp/pvv037

Maarman, G J, Schulz, R, Sliwa, K, Schermuly, R T, Lecour, S. 2017. Novel putative pharmacological therapies to protect the right ventricle in pulmonary hypertension: a review of current literature, British Journal of Pharmacology, Mnth April v. 174 (7) (p. 497-511)
doi: 10.1111/bph.13721

Victor, L. 2017. Investigating the possible cytoprotective effects of a melatonin isomer against simulated ischemic injury. MSc (Med). (p. 1-76) University of Cape Town, Cape Town.

– Record end –

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